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Infectious diseases

Central line and intravascular catheter infections

Diagnosing catheter-related bloodstream infection with paired cultures, when the line must come out, lock therapy, durations by organism, catheter-related thrombosis and the insertion bundle.

Tier 1Condition

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At a glance

  • Intravascular catheters cause a large share of healthcare-associated bloodstream infection, including S. aureus bacteraemia from peripheral cannulas, which are often forgotten.
  • Diagnosis rests on paired blood cultures (one through the catheter, one peripheral) and the absence of another source.
  • S. aureus, Pseudomonas, Candida and mycobacteria mean the line comes out. Coagulase-negative staphylococci can sometimes be treated with the line in place.

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Last updated
14 November 2026
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