Cutaneous manifestations of haematological disease and cutaneous lymphoma
Skin signs that point to a blood disorder (leukaemia cutis, Sweet syndrome, aquagenic pruritus, amyloid purpura, paraneoplastic pemphigus) and the primary cutaneous lymphomas: mycosis fungoides, Sézary syndrome, staging and EORTC 2023 stage-based treatment, with PBS chlormethine gel (2024) and mogamulizumab (2026).
Tier 2Condition
Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made
At a glance
- Skin findings in haematology fall into two groups: specific lesions, where malignant cells infiltrate the skin, and non-specific reactive or paraneoplastic changes.
- The commonest primary cutaneous lymphoma is mycosis fungoides (MF), a CD4 T-cell lymphoma that looks like eczema or psoriasis for years. Persistent "eczema" in sun-protected skin that fails treatment needs a biopsy.
- Early MF has a near-normal prognosis and gets skin-directed therapy only. Advanced disease and Sézary syndrome need a haematology or cutaneous lymphoma multidisciplinary team.
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Sources
- The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomasWillemze R et al., Blood 2019;133:1703-1714, 2018
- EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome: update 2023Latzka J et al., Eur J Cancer 2023;195:113343, 2023
- Revisions to the staging and classification of mycosis fungoides and Sézary syndrome (ISCL/EORTC)Olsen E et al., Blood 2007;110:1713-1722, 2007
- Mogamulizumab (Poteligeo) now listed on the PBSAU/NZLymphoma Australia, April 2026
- Ledaga (chlormethine gel) launched on the PBSAU/NZPharmacy Daily, November 2024
- Therapeutic Guidelines (eTG complete): dermatologyAU/NZTherapeutic Guidelines Limited
- Central hypothyroidism associated with retinoid X receptor-selective ligandsN Engl J Med (Sherman SI et al., 1999;340), 1999
- Targretin (bexarotene) capsules: prescribing informationUS National Library of Medicine (DailyMed)
- Last updated
- 14 November 2026
What changed
- 14 November 2026 Turnstile bot check on sign-in and signed-out feedback