Thrombophilia
Inherited and acquired thrombophilias, who to test and when (ASH 2023, BSH 2022), drug and timing effects on the assays, antiphospholipid syndrome and why it rules out most DOACs, and contraception and pregnancy decisions.
Tier 1Condition
Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made
At a glance
- Thrombophilia is a laboratory tendency to thrombosis. Most people with a heritable thrombophilia never clot, and most VTE occurs without one.
- Test only if the result will change management. ASH 2023, BSH 2022 and the 2019 THANZ VTE guideline all advise against routine testing.
- Anticoagulation duration after VTE depends mainly on whether the clot was provoked, not on heritable thrombophilia results.
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Sources
- New guidelines from the Thrombosis and Haemostasis Society of Australia and New Zealand for the diagnosis and management of venous thromboembolismAU/NZTran HA et al., Med J Aust 2019;210:227-35, 2019
- American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testingMiddeldorp S et al., Blood Adv 2023;7:7101-38, 2023
- Thrombophilia testing: a British Society for Haematology guidelineArachchillage DJ et al., Br J Haematol 2022;198:443-58, 2022
- EULAR recommendations for the management of antiphospholipid syndrome in adultsTektonidou MG et al., Ann Rheum Dis 2019;78:1296-304, 2019
- The 2023 ACR/EULAR antiphospholipid syndrome classification criteriaBarbhaiya M et al., Arthritis Rheumatol 2023;75:1687-702, 2023
- Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome (TRAPS)Pengo V et al., Blood 2018;132:1365-71, 2018
- American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancyBates SM et al., Blood Adv 2018;2:3317-59, 2018
- Medicare Benefits Schedule item 73308 (factor V Leiden and other relevant mutations)AU/NZAustralian Government Department of Health, Disability and Ageing
- Last updated
- 14 November 2026
What changed
- 14 November 2026 Personal emails, About story and Australian-style copy