Tracheobronchial secretions in the dying patient
Noisy respiratory secretions ("death rattle") in the last hours to days of life, what they predict, how to explain them to families, repositioning and fluid review, and where antimuscarinics such as hyoscine butylbromide and glycopyrronium fit given weak evidence.
Tier 1Approach to a presentation
Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made
At a glance
- Noisy, rattling breathing in a patient in the last hours to days of life, from secretions they can't clear. It affects roughly a third to a half of dying patients (reported range 23 to 92%).
- It is a sign of imminent death: most patients die within a day or two of onset, though a few live longer.
- There is no good evidence that the noise distresses the patient, who is usually unconscious. It distresses families and staff, and explaining it is the main intervention.
Loading the rest of the note…
Finished reading?
Sources
- Therapeutic Guidelines: Palliative Care (eTG complete), version 5AU/NZTherapeutic Guidelines Limited, 2024 (version 5, December 2024)
- Wee B, Hillier R. Interventions for noisy breathing in patients near to death. Cochrane Database Syst Rev 2008;(1):CD005177Cochrane, 2008, updated search 2009 (no later version at November 2026)
- van Esch HJ et al. Effect of prophylactic subcutaneous scopolamine butylbromide on death rattle in patients at the end of life: the SILENCE randomized clinical trial. JAMA 2021;326:1268-1276JAMA, 2021
- Wildiers H et al. Atropine, hyoscine butylbromide, or scopolamine are equally effective for the treatment of death rattle in terminal care. J Pain Symptom Manage 2009;38:124-133Journal of Pain and Symptom Management, 2009
- Hui D et al. Clinical signs of impending death in cancer patients. Oncologist 2014;19:681-687The Oncologist, 2014
- NICE guideline NG31: Care of dying adults in the last days of lifeNational Institute for Health and Care Excellence, 2015 (current at November 2026)
- Schedule of Pharmaceutical Benefits: Palliative Care (hyoscine butylbromide injection)AU/NZPharmaceutical Benefits Scheme, Australian Government, September 2026
- Last updated
- 14 November 2026
What changed
- 14 November 2026 Turnstile bot check on sign-in and signed-out feedback