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GI manifestations of systemic and chronic disease

Diabetic gastroparesis and diarrhoea, GLP-1 receptor agonists before endoscopy, GI amyloidosis and how to prove it, cystic fibrosis in the gut (pancreatic insufficiency, DIOS, liver, bowel cancer), carcinoid syndrome, and quick links for scleroderma, endocrine, renal and vascular disease.

Tier 2Topic overview

Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made

3 questions 8 flashcards

At a glance

Many systemic diseases show up first in the gut. Think of them when GI symptoms come with neuropathy, proteinuria, heart failure, skin change or an unusual drug history.
Curriculum focus: diabetes, amyloidosis, cystic fibrosis and neuroendocrine tumours.
Diabetes: gastroparesis, diarrhoea, drug effects, coeliac disease and MASLD.

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Sources

Therapeutic Guidelines: Gastrointestinal (eTG complete)AU/NZTherapeutic Guidelines Limited
ADS, ANZCA, GESA and NACOS. Clinical practice recommendations on the peri-procedural use of GLP-1/GIP receptor agonists. Anaesth Intensive Care 2025;53:300-6AU/NZAustralian Diabetes Society, ANZCA, GESA and NACOS, 2025
Camilleri M et al. ACG Clinical Guideline: Gastroparesis. Am J Gastroenterol 2022;117:1197-220American College of Gastroenterology, 2022
Hadjiliadis D et al. Cystic fibrosis colorectal cancer screening consensus recommendations. Gastroenterology 2018;154:736-45Cystic Fibrosis Foundation, 2018
ENETS 2022 guidance paper for carcinoid syndrome and carcinoid heart diseaseJournal of Neuroendocrinology (ENETS), 2022
Neuroendocrine neoplasms (NENs) consensus guidelinesAU/NZClinical Oncology Society of Australia (Cancer Council Australia)

Last updated: 14 November 2026

What changed

14 November 2026 Personal emails, About story and Australian-style copy