Male hypogonadism
Confirm with two morning fasting testosterone levels, use LH and FSH to split primary from secondary, look for prolactin, iron and pituitary causes, and reserve PBS testosterone for pathological hypogonadism in men not seeking fertility.
Tier 2Condition
Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made
At a glance
- Hypogonadism is a clinical syndrome plus consistently low testosterone. Low testosterone alone isn't enough.
- LH and FSH split it: high in primary (testicular) failure, low or inappropriately normal in secondary (hypothalamic or pituitary) failure.
- The Endocrine Society of Australia (ESA 2016) supports testosterone for pathological hypogonadism. It doesn't support treating age-related or obesity-related falls.
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Sources
- Yeap BB et al. Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy. Med J Aust 2016;205:173-8AU/NZEndocrine Society of Australia, 2016 (current; no later update found, November 2026)
- Yeap BB et al. Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations. Med J Aust 2016;205:228-31AU/NZEndocrine Society of Australia, 2016
- Bhasin S et al. Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2018;103:1715-44Endocrine Society, 2018 (current; no later update found, November 2026)
- Lincoff AM et al. Cardiovascular safety of testosterone-replacement therapy (TRAVERSE). N Engl J Med 2023;389:107-17N Engl J Med, 2023
- Wittert G et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM). Lancet Diabetes Endocrinol 2021;9:32-45AU/NZLancet Diabetes Endocrinol, 2021
- Pharmaceutical Benefits Scheme, testosterone (androgen deficiency restriction)AU/NZAustralian Government Department of Health, Disability and Ageing
- Last updated
- 14 November 2026
What changed
- 14 November 2026 Personal emails, About story and Australian-style copy